# Original figure. Tested Python3.14, NumPy2.3.5, Matplotlib3.10.7. # Run from the desired output directory; writes one same-basename PNG to CWD. from pathlib import Path import numpy as np import matplotlib matplotlib.use("Agg") import matplotlib.pyplot as plt plt.rcParams.update({"font.size":10,"figure.facecolor":"white","axes.facecolor":"white","savefig.facecolor":"white"}) beta=.1;delta=1e-5;gamma=.1 def J(u):return beta*u*u/(1+u*u) def K(u):return u**4/(1+u**4) def f(u,v):return J(u)-K(u)*v*v/(1+v*v)-delta*v def V(u): u=np.asarray(u,dtype=float);lo=np.zeros_like(u);hi=J(u)/delta+1 for _ in range(65): m=(lo+hi)/2;positive=f(u,m)>0;lo=np.where(positive,m,lo);hi=np.where(positive,hi,m) return (lo+hi)/2 def fu(u,v):return 2*beta*u/(1+u*u)**2-4*u**3/(1+u**4)**2*v*v/(1+v*v) def fv(u,v):return -2*K(u)*v/(1+v*v)**2-delta def wp(u):return 1-gamma*fu(u,V(u))/fv(u,V(u)) def bisect(fn,a,b): fa=fn(a) for _ in range(70): m=(a+b)/2 if fn(m)*fa>0:a=m else:b=m return (a+b)/2 left=bisect(wp,.15,.25);right=bisect(wp,.33,.5) wl=left+gamma*V(left);wr=right+gamma*V(right) ul=bisect(lambda u:u+gamma*V(u)-wr,1e-8,.1) ur=bisect(lambda u:u+gamma*V(u)-wl,1,30) def arrow(ax,x,y,i,color): j=min(i+max(1,len(x)//18),len(x)-1);ax.annotate("",xy=(x[j],y[j]),xytext=(x[i],y[i]),arrowprops=dict(arrowstyle="->",color=color,lw=1.8)) eps=.0005;u=np.unique(np.r_[np.geomspace(1e-5,.6,2000),np.linspace(.6,26,2000)]);v=V(u) fig,axes=plt.subplots(1,2,figsize=(11,4.5),layout='constrained') for ax,mu,ylim in zip(axes,[.03,1.],[(0,12),(0,1.6)]): ax.plot(u,v,color='black',lw=1,label='$v$ nullcline $f=0$');rhs=eps/gamma*(mu-u);lo=np.zeros_like(u);hi=(J(u)-rhs)/delta+2;valid=J(u)>=rhs;hi=np.maximum(hi,1) for _ in range(65): m=(lo+hi)/2;pos=f(u,m)>rhs;lo=np.where(pos,m,lo);hi=np.where(pos,hi,m) un=(lo+hi)/2;ax.plot(u,np.where(valid,un,np.nan),'--',color='tab:orange',lw=1,label='$u$ nullcline') initial=bisect(lambda z:z+gamma*V(z)-25,right,25);ax.plot([25,initial],[0,V(initial)],color='tab:red',lw=2);ax.annotate('Fast store loading',xy=(initial,.18),xytext=(2,.8 if mu==1 else 2.6),arrowprops=dict(arrowstyle='->',color='tab:red'),color='tab:red',fontsize=8) end=right if mu',color='tab:red',lw=1.6)) a=np.linspace(ul,mu,700);vv=V(a);ax.plot(a,vv,color='tab:green',lw=2.5);arrow(ax,a,vv,350,'tab:green') ax.plot(mu,V(mu),'o',color='tab:purple',label='Stable equilibrium');ax.set_xscale('symlog',linthresh=.5);ax.set(xlim=(0,26),ylim=ylim,xlabel='Cytoplasmic calcium $u$ (compressed beyond 0.5)',ylabel='Store calcium $v$',title=f'Input $\\mu={mu:g}$: leading fast/slow geometry');ax.grid(alpha=.2) axes[0].legend(fontsize=7,loc='upper right');axes[1].legend(fontsize=7,loc='upper right');fig.suptitle('Schematic separated paths; finite-$\\epsilon$ trajectories round the folds',fontsize=11) fig.savefig(Path.cwd()/"2009-calcium-phase-plane.png",dpi=150)