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1Sex speeds adaptation by altering the dynamics of molecular evolution by Michael J. McDonald and otherssex-speeds-adaptation-by-altering-the-dynamics-of-molecular-evolution-by-michael-j-mcdonald-and-others2026-10-202026-10-20
1The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants by Christiane Rayssiguier and othersthe-barrier-to-recombination-between-escherichia-coli-and-salmonella-typhimurium-is-disrupted-in-mismatch-repair-mutants-by-christiane-rayssiguier-and-others2026-10-202026-10-20
1Genomic imprinting is disrupted in interspecific Peromyscus hybrids by Paul B. Vrana and othersgenomic-imprinting-is-disrupted-in-interspecific-peromyscus-hybrids-by-paul-b-vrana-and-others2026-10-202026-10-20
1Sex ratio and unisexual sterility in hybrid animals by J. B. S. Haldanesex-ratio-and-unisexual-sterility-in-hybrid-animals-by-j-b-s-haldane2026-10-202026-10-20
1Plasticity-led evolution: evaluating the key prediction of frequency-dependent adaptation by Nicholas A. Levis and David W. Pfennigplasticity-led-evolution-evaluating-the-key-prediction-of-frequency-dependent-adaptation-by-nicholas-a-levis-and-david-w-pfennig2026-10-202026-10-20
1SAINT: probabilistic scoring of affinity purification-mass spectrometry data by Hyungwon Choi and otherssaint-probabilistic-scoring-of-affinity-purification-mass-spectrometry-data-by-hyungwon-choi-and-others2026-10-202026-10-20
1A human interactome in three quantitative dimensions organized by stoichiometries and abundances by Marco Y. Hein and othersa-human-interactome-in-three-quantitative-dimensions-organized-by-stoichiometries-and-abundances-by-marco-y-hein-and-others2026-10-202026-10-20
1Efficient proximity labeling in living cells and organisms with TurboID by Tess C. Branon and othersefficient-proximity-labeling-in-living-cells-and-organisms-with-turboid-by-tess-c-branon-and-others2026-10-202026-10-20
1Accurate structure prediction of biomolecular interactions with AlphaFold 3 by Josh Abramson and othersaccurate-structure-prediction-of-biomolecular-interactions-with-alphafold-3-by-josh-abramson-and-others2026-10-202026-10-20
1The dynamic energy landscape of dihydrofolate reductase catalysis by David D. Boehr and othersthe-dynamic-energy-landscape-of-dihydrofolate-reductase-catalysis-by-david-d-boehr-and-others2026-10-202026-10-20
1Structural insights into the dynamic process of β2-adrenergic receptor signaling by Aashish Manglik and othersstructural-insights-into-the-dynamic-process-of-beta-2-adrenergic-receptor-signaling-by-aashish-manglik-and-others2026-10-202026-10-20
1Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures by Zhucheng Chen and othersmechanism-of-homologous-recombination-from-the-reca-ssdna-dsdna-structures-by-zhucheng-chen-and-others2026-10-202026-10-20
1Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange by Jingfei Xu and otherscryo-em-structures-of-human-rad51-recombinase-filaments-during-catalysis-of-dna-strand-exchange-by-jingfei-xu-and-others2026-10-202026-10-20
1Mechanism of strand exchange from RecA–DNA synaptic and D-loop structures by Haijuan Yang and othersmechanism-of-strand-exchange-from-reca-dna-synaptic-and-d-loop-structures-by-haijuan-yang-and-others2026-10-202026-10-20
1MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy by Shawn Q. Zheng and othersmotioncor2-anisotropic-correction-of-beam-induced-motion-for-improved-cryo-electron-microscopy-by-shawn-q-zheng-and-others2026-10-202026-10-20
1Single-particle cryo-EM at atomic resolution by Takanori Nakane and otherssingle-particle-cryo-em-at-atomic-resolution-by-takanori-nakane-and-others2026-10-202026-10-20
1Atomic-resolution protein structure determination by cryo-EM by Ka Man Yip and othersatomic-resolution-protein-structure-determination-by-cryo-em-by-ka-man-yip-and-others2026-10-202026-10-20
1RELION: implementation of a Bayesian approach to cryo-EM structure determination by Sjors H. W. Scheresrelion-implementation-of-a-bayesian-approach-to-cryo-em-structure-determination-by-sjors-h-w-scheres2026-10-202026-10-20
1Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site by Mohammad T. Mazhab-Jafari and othersoncogenic-and-rasopathy-associated-k-ras-mutations-relieve-membrane-dependent-occlusion-of-the-effector-binding-site-by-mohammad-t-mazhab-jafari-and-others2026-10-202026-10-20
1PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling by Hsin-Yung Yen and othersptdins-4-5-p2-stabilizes-active-states-of-gpcrs-and-enhances-selectivity-of-g-protein-coupling-by-hsin-yung-yen-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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