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1Villification in the mouse: Bmp signals control intestinal villus patterning by Katherine D. Walton and othersvillification-in-the-mouse-bmp-signals-control-intestinal-villus-patterning-by-katherine-d-walton-and-others2026-10-202026-10-20
1Identification of stem cells in small intestine and colon by marker gene Lgr5 by Nick Barker and othersidentification-of-stem-cells-in-small-intestine-and-colon-by-marker-gene-lgr5-by-nick-barker-and-others2026-10-202026-10-20
1Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche by Toshiro Sato and otherssingle-lgr5-stem-cells-build-crypt-villus-structures-in-vitro-without-a-mesenchymal-niche-by-toshiro-sato-and-others2026-10-202026-10-20
1Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters by Paul W. Tetteh and othersreplacement-of-lost-lgr5-positive-stem-cells-through-plasticity-of-their-enterocyte-lineage-daughters-by-paul-w-tetteh-and-others2026-10-202026-10-20
1Dedifferentiation of committed epithelial cells into stem cells in vivo by Purushothama Rao Tata and othersdedifferentiation-of-committed-epithelial-cells-into-stem-cells-in-vivo-by-purushothama-rao-tata-and-others2026-10-202026-10-20
1Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status by Iwo Kucinski and otherschronic-activation-of-jnk-jak-stat-and-oxidative-stress-signalling-causes-the-loser-cell-status-by-iwo-kucinski-and-others2026-10-202026-10-20
1Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation by David Fernandez-Antoran and othersoutcompeting-p53-mutant-cells-in-the-normal-esophagus-by-redox-manipulation-by-david-fernandez-antoran-and-others2026-10-202026-10-20
1Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium by Makoto Horiuchi and otherscellular-nrf2-levels-determine-cell-fate-during-chemical-carcinogenesis-in-esophageal-epithelium-by-makoto-horiuchi-and-others2026-10-202026-10-20
1Positional information and the spatial pattern of cellular differentiation by Lewis Wolpertpositional-information-and-the-spatial-pattern-of-cellular-differentiation-by-lewis-wolpert2026-10-202026-10-20
1Sonic hedgehog mediates the polarizing activity of the ZPA by Robert D. Riddle and otherssonic-hedgehog-mediates-the-polarizing-activity-of-the-zpa-by-robert-d-riddle-and-others2026-10-202026-10-20
1Cells keep a memory of their tissue origin during axolotl limb regeneration by Martin Kragl and otherscells-keep-a-memory-of-their-tissue-origin-during-axolotl-limb-regeneration-by-martin-kragl-and-others2026-10-202026-10-20
1Vitamin A and pattern formation in the regenerating limb by Malcolm Madenvitamin-a-and-pattern-formation-in-the-regenerating-limb-by-malcolm-maden2026-10-202026-10-20
1FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration by Eugen Nacu and othersfgf8-and-shh-substitute-for-anterior-posterior-tissue-interactions-to-induce-limb-regeneration-by-eugen-nacu-and-others2026-10-202026-10-20
1An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation by Owen W. J. Prall and othersan-nkx2-5-bmp2-smad1-negative-feedback-loop-controls-heart-progenitor-specification-and-proliferation-by-owen-w-j-prall-and-others2026-10-202026-10-20
1Multiple essential functions of neuregulin in development by Dirk Meyer and Carmen Birchmeiermultiple-essential-functions-of-neuregulin-in-development-by-dirk-meyer-and-carmen-birchmeier2026-10-202026-10-20
1Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size by Todd Heallen and othershippo-pathway-inhibits-wnt-signaling-to-restrain-cardiomyocyte-proliferation-and-heart-size-by-todd-heallen-and-others2026-10-202026-10-20
1Transient regenerative potential of the neonatal mouse heart by Enzo R. Porrello and otherstransient-regenerative-potential-of-the-neonatal-mouse-heart-by-enzo-r-porrello-and-others2026-10-202026-10-20
1Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis by Aron B. Jaffe and otherscdc42-controls-spindle-orientation-to-position-the-apical-surface-during-epithelial-morphogenesis-by-aron-b-jaffe-and-others2026-10-202026-10-20
1Patterned gene expression directs bipolar planar polarity in Drosophila by Jennifer A. Zallen and Eric Wieschauspatterned-gene-expression-directs-bipolar-planar-polarity-in-drosophila-by-jennifer-a-zallen-and-eric-wieschaus2026-10-202026-10-20
1Pulsed contractions of an actin-myosin network drive apical constriction by Adam C. Martin and otherspulsed-contractions-of-an-actin-myosin-network-drive-apical-constriction-by-adam-c-martin-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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