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1The earliest known fully quadrupedal sirenian by Daryl P. Domningthe-earliest-known-fully-quadrupedal-sirenian-by-daryl-p-domning2026-10-202026-10-20
1Parallel adaptive radiations in two major clades of placental mammals by Ole Madsen and othersparallel-adaptive-radiations-in-two-major-clades-of-placental-mammals-by-ole-madsen-and-others2026-10-202026-10-20
1Phylogenetic relationships among cetartiodactyls based on insertions of short and long interspersed elements: hippopotamuses are the closest extant relatives of whales by Masato Nikaido and othersphylogenetic-relationships-among-cetartiodactyls-based-on-insertions-of-short-and-long-interspersed-elements-hippopotamuses-are-the-closest-extant-relatives-of-whales-by-masato-nikaido-and-others2026-10-202026-10-20
1A species-level timeline of mammal evolution integrating phylogenomic data by Sandra Álvarez-Carretero and othersa-species-level-timeline-of-mammal-evolution-integrating-phylogenomic-data-by-sandra-alvarez-carretero-and-others2026-10-202026-10-20
1The placental mammal ancestor and the post-K-Pg radiation of placentals by Maureen A. O'Leary and othersthe-placental-mammal-ancestor-and-the-post-k-pg-radiation-of-placentals-by-maureen-a-o-leary-and-others2026-10-202026-10-20
1Meckel’s cartilage breakdown offers clues to mammalian middle ear evolution by Neal Anthwal and othersmeckel’s-cartilage-breakdown-offers-clues-to-mammalian-middle-ear-evolution-by-neal-anthwal-and-others2026-10-202026-10-20
1Ancient proteins resolve the evolutionary history of Darwin's South American ungulates by Frido Welker and othersancient-proteins-resolve-the-evolutionary-history-of-darwin-s-south-american-ungulates-by-frido-welker-and-others2026-10-202026-10-20
1Million-year-old DNA sheds light on the genomic history of mammoths by Tom van der Valk and othersmillion-year-old-dna-sheds-light-on-the-genomic-history-of-mammoths-by-tom-van-der-valk-and-others2026-10-202026-10-20
1Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule by Akiyuki Nishimura and othersstructural-basis-for-the-specific-inhibition-of-heterotrimeric-gq-protein-by-a-small-molecule-by-akiyuki-nishimura-and-others2026-10-202026-10-20
1The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity by Jude Canon and othersthe-clinical-kras-g12c-inhibitor-amg-510-drives-anti-tumour-immunity-by-jude-canon-and-others2026-10-202026-10-20
1A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine by Scott M. DeWire and othersa-g-protein-biased-ligand-at-the-mu-opioid-receptor-is-potently-analgesic-with-reduced-gastrointestinal-and-respiratory-dysfunction-compared-with-morphine-by-scott-m-dewire-and-others2026-10-202026-10-20
1Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists by Alexander Gillis and otherslow-intrinsic-efficacy-for-g-protein-activation-can-explain-the-improved-side-effect-profiles-of-new-opioid-agonists-by-alexander-gillis-and-others2026-10-202026-10-20
1Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication by Piers Nash and othersmultisite-phosphorylation-of-a-cdk-inhibitor-sets-a-threshold-for-the-onset-of-dna-replication-by-piers-nash-and-others2026-10-202026-10-20
1Phase transitions in the assembly of multivalent signalling proteins by Pilong Li and othersphase-transitions-in-the-assembly-of-multivalent-signalling-proteins-by-pilong-li-and-others2026-10-202026-10-20
1Mapping intact protein isoforms in discovery mode using top-down proteomics by John C. Tran and othersmapping-intact-protein-isoforms-in-discovery-mode-using-top-down-proteomics-by-john-c-tran-and-others2026-10-202026-10-20
1EF-P is essential for rapid synthesis of proteins containing consecutive proline residues by Lili K. Doerfel and othersef-p-is-essential-for-rapid-synthesis-of-proteins-containing-consecutive-proline-residues-by-lili-k-doerfel-and-others2026-10-202026-10-20
1Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches by Susanne Ude and otherstranslation-elongation-factor-ef-p-alleviates-ribosome-stalling-at-polyproline-stretches-by-susanne-ude-and-others2026-10-202026-10-20
1Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution by Konstantin Pervushin and othersattenuated-t2-relaxation-by-mutual-cancellation-of-dipole-dipole-coupling-and-chemical-shift-anisotropy-indicates-an-avenue-to-nmr-structures-of-very-large-biological-macromolecules-in-solution-by-konstantin-pervushin-and-others2026-10-202026-10-20
1Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins by Franz Hagn and othersoptimized-phospholipid-bilayer-nanodiscs-facilitate-high-resolution-structure-determination-of-membrane-proteins-by-franz-hagn-and-others2026-10-202026-10-20
1Structure of fully protonated proteins by proton-detected magic-angle spinning NMR by Loren B. Andreas and othersstructure-of-fully-protonated-proteins-by-proton-detected-magic-angle-spinning-nmr-by-loren-b-andreas-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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