Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Top New A-Z
Articles Title Id Created Updated
1Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons by Orly L. Wapinski and othershierarchical-mechanisms-for-direct-reprogramming-of-fibroblasts-to-neurons-by-orly-l-wapinski-and-others2026-10-202026-10-20
1Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding by David J. Haile and otherscellular-regulation-of-the-iron-responsive-element-binding-protein-disassembly-of-the-cubane-iron-sulfur-cluster-results-in-high-affinity-rna-binding-by-david-j-haile-and-others2026-10-202026-10-20
1An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis by Ameen A. Salahudeen and othersan-e3-ligase-possessing-an-iron-responsive-hemerythrin-domain-is-a-regulator-of-iron-homeostasis-by-ameen-a-salahudeen-and-others2026-10-202026-10-20
1Identification of the iron-responsive element for the translational regulation of human ferritin mRNA by Matthias W. Hentze and othersidentification-of-the-iron-responsive-element-for-the-translational-regulation-of-human-ferritin-mrna-by-matthias-w-hentze-and-others2026-10-202026-10-20
1Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation by John L. Casey and othersiron-responsive-elements-regulatory-rna-sequences-that-control-mrna-levels-and-translation-by-john-l-casey-and-others2026-10-202026-10-20
1Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation by Sergi Puig and otherscoordinated-remodeling-of-cellular-metabolism-during-iron-deficiency-through-targeted-mrna-degradation-by-sergi-puig-and-others2026-10-202026-10-20
1Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA by Thomas Dandekar and othersidentification-of-a-novel-iron-responsive-element-in-murine-and-human-erythroid-delta-aminolevulinic-acid-synthase-mrna-by-thomas-dandekar-and-others2026-10-202026-10-20
1The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA by Juan Valcárcel and othersthe-protein-sex-lethal-antagonizes-the-splicing-factor-u2af-to-regulate-alternative-splicing-of-transformer-pre-mrna-by-juan-valcarcel-and-others2026-10-202026-10-20
1Splicing regulation at the second catalytic step by Sex-lethal involves 3′ splice site recognition by SPF45 by María José Lallena and otherssplicing-regulation-at-the-second-catalytic-step-by-sex-lethal-involves-3′-splice-site-recognition-by-spf45-by-maria-jose-lallena-and-others2026-10-202026-10-20
1Structure of PTB bound to RNA: specific binding and implications for splicing regulation by Florian C. Oberstrass and othersstructure-of-ptb-bound-to-rna-specific-binding-and-implications-for-splicing-regulation-by-florian-c-oberstrass-and-others2026-10-202026-10-20
1RNA looping by PTB: evidence using FRET and NMR spectroscopy for a role in splicing repression by Rajan Lamichhane and othersrna-looping-by-ptb-evidence-using-fret-and-nmr-spectroscopy-for-a-role-in-splicing-repression-by-rajan-lamichhane-and-others2026-10-202026-10-20
1Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB by Miriam Llorian and othersposition-dependent-alternative-splicing-activity-revealed-by-global-profiling-of-alternative-splicing-events-regulated-by-ptb-by-miriam-llorian-and-others2026-10-202026-10-20
1Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules by Daniel Mateju and otherssingle-molecule-imaging-reveals-translation-of-mrnas-localized-to-stress-granules-by-daniel-mateju-and-others2026-10-202026-10-20
1G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits by Nancy Kedersha and othersg3bp-caprin1-usp10-complexes-mediate-stress-granule-condensation-and-associate-with-40s-subunits-by-nancy-kedersha-and-others2026-10-202026-10-20
1Crystal structure of the nucleosome core particle at 2.8 Å resolution by Karolin Luger and otherscrystal-structure-of-the-nucleosome-core-particle-at-2-8-a-resolution-by-karolin-luger-and-others2026-10-202026-10-20
1Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position by Jason D. Buenrostro and otherstransposition-of-native-chromatin-for-fast-and-sensitive-epigenomic-profiling-of-open-chromatin-dna-binding-proteins-and-nucleosome-position-by-jason-d-buenrostro-and-others2026-10-202026-10-20
1ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells by Horng D. Ou and otherschromemt-visualizing-3d-chromatin-structure-and-compaction-in-interphase-and-mitotic-cells-by-horng-d-ou-and-others2026-10-202026-10-20
1A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping by Suhas S. P. Rao and othersa-3d-map-of-the-human-genome-at-kilobase-resolution-reveals-principles-of-chromatin-looping-by-suhas-s-p-rao-and-others2026-10-202026-10-20
1Cohesin loss eliminates all loop domains by Suhas S. P. Rao and otherscohesin-loss-eliminates-all-loop-domains-by-suhas-s-p-rao-and-others2026-10-202026-10-20
1Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase by Bas van Steensel and Steven Henikoffidentification-of-in-vivo-dna-targets-of-chromatin-proteins-using-tethered-dam-methyltransferase-by-bas-van-steensel-and-steven-henikoff2026-10-202026-10-20

Empty topics are being shown, click here to show only nonempty topics.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
Site settings