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1Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras by Erica L. Jackson and othersanalysis-of-lung-tumor-initiation-and-progression-using-conditional-expression-of-oncogenic-k-ras-by-erica-l-jackson-and-others2026-10-202026-10-20
1Patient-derived xenografts undergo mouse-specific tumor evolution by Uri Ben-David and otherspatient-derived-xenografts-undergo-mouse-specific-tumor-evolution-by-uri-ben-david-and-others2026-10-202026-10-20
1High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading by Robert E. Goldsby and othershigh-incidence-of-epithelial-cancers-in-mice-deficient-for-dna-polymerase-delta-proofreading-by-robert-e-goldsby-and-others2026-10-202026-10-20
1Human mismatch repair: reconstitution of a nick-directed bidirectional reaction by Nicoleta Constantin and othershuman-mismatch-repair-reconstitution-of-a-nick-directed-bidirectional-reaction-by-nicoleta-constantin-and-others2026-10-202026-10-20
1Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair by Micheline Strand and othersdestabilization-of-tracts-of-simple-repetitive-dna-in-yeast-by-mutations-affecting-dna-mismatch-repair-by-micheline-strand-and-others2026-10-202026-10-20
1RNase H2-initiated ribonucleotide excision repair by Justin L. Sparks and othersrnase-h2-initiated-ribonucleotide-excision-repair-by-justin-l-sparks-and-others2026-10-202026-10-20
1RAS is regulated by the let-7 microRNA family by Steven M. Johnson and othersras-is-regulated-by-the-let-7-microrna-family-by-steven-m-johnson-and-others2026-10-202026-10-20
1Suppression of non-small cell lung tumor development by the let-7 microRNA family by Manish S. Kumar and otherssuppression-of-non-small-cell-lung-tumor-development-by-the-let-7-microrna-family-by-manish-s-kumar-and-others2026-10-202026-10-20
1The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia by Ulf Klein and othersthe-dleu2-mir-15a-16-1-cluster-controls-b-cell-proliferation-and-its-deletion-leads-to-chronic-lymphocytic-leukemia-by-ulf-klein-and-others2026-10-202026-10-20
1A microRNA component of the p53 tumour suppressor network by Lin He and othersa-microrna-component-of-the-p53-tumour-suppressor-network-by-lin-he-and-others2026-10-202026-10-20
1Intact p53-dependent responses in miR-34-deficient mice by Carla P. Concepcion and othersintact-p53-dependent-responses-in-mir-34-deficient-mice-by-carla-p-concepcion-and-others2026-10-202026-10-20
1Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours by David S. Hong and othersphase-1-study-of-mrx34-a-liposomal-mir-34a-mimic-in-patients-with-advanced-solid-tumours-by-david-s-hong-and-others2026-10-202026-10-20
1Highly accurate protein structure prediction with AlphaFold by John Jumper and othershighly-accurate-protein-structure-prediction-with-alphafold-by-john-jumper-and-others2026-10-202026-10-20
1Robust perfect adaptation in bacterial chemotaxis through integral feedback control by Tau-Mu Yi and othersrobust-perfect-adaptation-in-bacterial-chemotaxis-through-integral-feedback-control-by-tau-mu-yi-and-others2026-10-202026-10-20
1Gene name errors are widespread in the scientific literature by Mark Ziemann and othersgene-name-errors-are-widespread-in-the-scientific-literature-by-mark-ziemann-and-others2026-10-202026-10-20
1FMRI Clustering in AFNI: False-Positive Rates Redux by Robert W. Cox and othersfmri-clustering-in-afni-false-positive-rates-redux-by-robert-w-cox-and-others2026-10-202026-10-20
1A whole-cell computational model predicts phenotype from genotype by Jonathan R. Karr and othersa-whole-cell-computational-model-predicts-phenotype-from-genotype-by-jonathan-r-karr-and-others2026-10-202026-10-20
1The embryonic cell lineage of the nematode Caenorhabditis elegans by John Sulston and othersthe-embryonic-cell-lineage-of-the-nematode-caenorhabditis-elegans-by-john-sulston-and-others2026-10-202026-10-20
1A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution by Jonathan S. Packer and othersa-lineage-resolved-molecular-atlas-of-c-elegans-embryogenesis-at-single-cell-resolution-by-jonathan-s-packer-and-others2026-10-202026-10-20
1OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans by Gopal P. Sarma and othersopenworm-overview-and-recent-advances-in-integrative-biological-simulation-of-caenorhabditis-elegans-by-gopal-p-sarma-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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