AMG 510
= AMG 510
{c}
= Sotorasib
{synonym}
A covalent inhibitor developed against <KRAS G12C protein>, also called <sotorasib>. Its state-dependent binding illustrates targeting a mutant <small GTPase> outside the nucleotide site.<The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity by Jude Canon and others>[Chemical and preclinical characterization]{ref}