Andrew J. Brooks
= Andrew J. Brooks
{c}
<Andrew J. Brooks> studies <signal transduction> by <cytokine receptors>, particularly the <growth hormone receptor> and its associated <protein kinase> <JAK2>. The research asks how an extracellular binding event changes the arrangement and activity of intracellular signaling machinery.<Andrew Brooks research profile at the University of New England>[Biographical Details and Research Interests]{ref}
In a 2014 study, <Andrew J. Brooks> and collaborators combined <Förster resonance energy transfer>, engineered receptor substitutions and structural modeling. They monitored the positions of <JAK2>-binding regions in the receptor pair. Their model connected receptor activation to a change in transmembrane geometry that separates these binding regions and relieves inhibition involving the <pseudokinase> region of <JAK2>.<Mechanism of activation of protein kinase JAK2 by the growth hormone receptor by Andrew J. Brooks and others>[Abstract: FRET, controlled receptor geometry and kinase/pseudokinase model]{ref}
The illuminating example is a pair that already exists before activation: a change in relative orientation can matter as much as bringing two molecules together. The combination of distance-sensitive measurements, engineered perturbations and structural models tests this idea more directly than merely observing that a <hormone> and receptor bind. The proposed sequence is a mechanistic model assembled from complementary evidence.
\Image[https://researchers.une.edu.au/files-asset/86313573/Head.jpg?f=jpg&w=160]
{title=Andrew J. Brooks}
{description=Portrait labelled Andrew Brooks on the https://researchers.une.edu.au/en/persons/andrew-brooks/[institutional profile], which identifies the growth-hormone-receptor research program and Brooks,A.J. publications.}
{height=240}