= ARF GTPase
{c}
= ARF-family GTPase
{c}
{synonym}
An <ARF GTPase> is a small GTP-binding <protein> involved in membrane organization and coat recruitment. <Nucleotide> exchange promotes a membrane-associated active state that recruits selected effectors, while <hydrolysis> contributes to turnover of the assembly. ARF1 is a prominent regulator of <coatomer> recruitment at Golgi-associated membranes. Different family members and effectors act in different locations, so the family name does not specify one universal cargo route. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 13, Coat proteins and vesicle budding: ARF and COPI]{ref}
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