{c}

<Ascl2> is a basic helix-loop-helix <transcription factor> associated with intestinal stem-cell identity and regeneration. Its activity can help differentiated-lineage descendants reacquire a stem-like programme after injury. This is a conditional regenerative response, rather than proof that every <Ascl2>-expressing <cell> has unlimited <self-renewal>. <Genetic perturbation> and lineage measurements connect the regulator to the recovery process. <Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells by Kazutaka Murata and others>[2020, injury-associated dedifferentiation and Ascl2 dependence]{ref}


 Ascl2 (source code)