= Asymmetric cell division
<Asymmetric cell division> produces daughter <cells> with different developmental fates. Unequal size can accompany it, but the defining distinction is the daughters' outcomes. An asymmetry may arise from unequal inheritance of intracellular components or from different access to a <stem-cell niche> after division. For example, one daughter of a <germline stem cell> can retain its niche contact while the other begins <cell differentiation>. This couples <cell polarity>, <spindle apparatus> orientation and local signalling. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 22, Stem Cells: asymmetric division and self-renewal]{ref}
In the male <Drosophila> germline, a localized Bazooka patch provides a <centrosome> docking platform. Reducing Bazooka disrupted <centrosome> orientation; ectopic patches could associate with misplaced <centrosomes>. Measurements of both interphase <centrosomes> and mitotic <spindle apparatus> helped separate orientation defects from failure of the checkpoint that normally delays division. <The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline by Mayu Inaba and others>[2015, Figure 3 and results: Baz knockdown, overexpression and orientation checkpoint]{ref}
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