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An asymmetric oxidation is an oxidation that favours one stereochemical outcome, often by using a chiral catalyst. Asymmetric epoxidation and asymmetric dihydroxylation are examples: an oxygen-transfer process also creates controlled spatial structure.^[ref]

Oxidation state change and enantioselectivity describe different aspects of the result. A high chemical yield therefore does not by itself establish a high enantiomeric excess.

Karl Barry Sharpless developed methods for asymmetric oxidation, including Sharpless asymmetric epoxidation and asymmetric dihydroxylation. A chiral catalyst makes one enantiomer form preferentially, giving synthetic chemists control over molecular handedness as well as molecular connectivity.^[ref]