Ball-and-chain inactivation
= Ball-and-chain inactivation
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= N-type inactivation
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{synonym}
A tethered intracellular particle blocks an open <ion channel> from the cytoplasmic side. In classical Shaker-type channels the particle is N-terminal: removing it suppresses fast inactivation, while cytoplasmic application of a corresponding peptide can restore block. The pore-blocking mechanism differs from ordinary activation-gate closure.