= Bart J. Janssen
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<Bart J. Janssen> studies the molecular control of <plant> development. A 2008 study led by Janssen followed <gene expression> as <apple> <fruits> developed, linking molecular measurements to recognizable changes in anatomy and growth.
The investigators collected samples at eight developmental times and used a <DNA microarray> representing approximately 13000 <genes>. Four broad temporal patterns distinguished <flower> stages, early <cell division>, growth with <starch> accumulation, and <ripening>. Selected measurements were checked using <Quantitative PCR>.<Global gene expression analysis of apple fruit development from the floral bud to ripe fruit by Bart J. Janssen and others>[BMC Plant Biology 8:16; Abstract and Results, microarray analysis and validation by quantitative RT-PCR]{ref}
An <apple> is a <pome>, with both an <ovary (botany)>-derived core and surrounding <hypanthium> tissue. Comparing stages therefore asks how growth of a composite <fruit> is coordinated. A <gene> whose expression peaks during <cell division> becomes a candidate for further investigation; matching the timing does not alone demonstrate that the <gene> causes that developmental change.<Global gene expression analysis of apple fruit development from the floral bud to ripe fruit by Bart J. Janssen and others>[Background, core/cortex distinction; Results, coordinated expression patterns]{ref}
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