= Bert J. C. Janssen
{c}
<Bert J. C. Janssen> is the first author of a 2005 structural study of <Complement C3> and its processed fragment <C3c>. The team determined <crystal structures> that connected the arrangement of <protein domains> to activation and regulation in the <complement system>.<Structures of complement component C3 provide insights into the function and evolution of immunity by Bert J. C. Janssen and others>[Original full byline and Abstract]{ref}
The structures helped explain how a reactive <thioester>, needed for later covalent attachment, can remain protected against premature <hydrolysis>. Comparing the native and processed forms also revealed substantial changes in domain arrangement.<Structures of complement component C3 provide insights into the function and evolution of immunity by Bert J. C. Janssen and others>[Abstract; Figures 1–2 and 4]{ref}
The comparison is specifically <Complement C3> versus <C3c>. It is not a direct pair of structures showing native <Complement C3> and active <C3b>. Keeping the fragments distinct matters because different stages of processing have different biological roles: an informative structural difference is not automatically the exact movement that creates an active intermediate.
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{title=<Bert J. C. Janssen>}
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