Biased agonism
= Biased agonism
Preferential activation of one receptor-linked response relative to another, defined against a reference <ligand> and appropriate system controls. Different amplification or <receptor reserve> can mimic apparent bias.<Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists by Alexander Gillis and others>[Comparison of G protein efficacy and bias]{ref}