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The forms of ancient mania are innumerable in their varieties, but there is only one general kind: taken as a whole, it is a lasting derangement of the mind without fever. For if fever should at some time also occur, it would not arise as a feature peculiar to the ancient mania, but from some other coinciding cause. Thus wine also inflames the mind into delirious behaviour in drunkenness, and some things that are eaten, such as mandrake and henbane, drive people out of their minds. Yet these conditions are not called ancient mania: arising from a temporary cause, they settle more quickly, whereas ancient mania has persistence.

The senile dotage that is a misfortune of old age is quite unlike this ancient mania. It is a torpor of sensation and a numbing of judgement and intellect through coldness; ancient mania, by contrast, has something hot and dry in its cause and is turbulent in its actions. For senile dotage beginning in old age neither remits nor leaves the sufferer before death, whereas ancient mania does remit and, with care, can come to a complete end.

But a remission is incomplete when it occurs in keeping with the course of the ancient mania, without the illness having been properly cured by treatment or by the mildness of the season. For in some people who seemed to be unharmed, the spring season, an error in their way of life, or anger arising from some incident has brought the condition back.

Aretaeus of Cappadocia distinguishes persistent mental illness, transient intoxication and the cognitive decline attributed to old age. The opening of On the Causes and Signs of Chronic Diseases by Aretaeus of Cappadocia, I.6, organizes these distinctions by persistence, attributed cause and course, ending with examples of relapse. ^[ref]

Several terms need historical interpretation. “Derangement” renders a displacement from one's ordinary mental state, not a diagnosis based on a modern symptom checklist. “Way of life” includes diet and regimen; it is wider than a single meal. The sentence about incomplete remission concerns an apparent improvement within the illness's course, distinguished from a thorough cure through treatment or favourable seasonal conditions. A quiet interval can therefore be followed by recurrence. The hot, dry and cold explanations are historical physiology, not established modern causes.

The scope of ancient mania is broader than present-day mania. Current assessment examines the course of mood and activity changes, symptoms between episodes, medication and substance exposure, physical illness and alternative diagnoses; it does not define the disorder simply as every persistent mental disturbance without fever. Nor should historical senile dotage be equated with a precise diagnosis of one modern dementia, or the passage's assertions about old age be accepted as a modern prognosis. ^[ref]

Historical “acute mania” in women must be separated into a manic syndrome, psychosis associated with childbirth and disturbed behaviour caused by physical disease or drugs. Reproductive events can be clinically relevant without making female anatomy a sufficient explanation for mental illness.

A typical manic episode involves a marked change from the person's usual state: elevated or irritable mood, increased activity, little felt need for sleep, rapid or pressured speech, distractibility, impulsive decisions and exaggerated confidence. Severe illness can include delusions, hallucinations, disorganization and dangerous loss of judgement. Physical exhaustion or failure to eat can follow sustained activity. These are possible features of the syndrome, not assertions about an unspecified woman.^[ref] Fluctuating attention, disorientation, fever or a changing level of consciousness instead prompts particular concern for delirium and its cause.

In an 1866 account, chief associations would include the puerperal period, prolonged nursing with exhaustion, previous attacks, family predisposition, severe emotional disturbance and general illness. Historical “puerperal insanity” also included depressive and psychotic presentations, not just what is now called bipolar disorder. A contemporary journal summary distinguished pregnancy, puerperal and lactational groups and noted hereditary associations, recurrence and suicidal behaviour. Its observed associations do not establish menstrual suppression or nursing itself as a single sufficient cause.^[ref]

The practical historical aims were protection from injury, restoration of sleep and nutrition, a calm environment, attentive nursing and treatment of physical illness. Someone unable to care safely for herself or an infant required continuous help. Opiates, baths and other sedating measures were tried; quietness after sedation did not prove cure. Depleting a person already exhausted by childbirth or blood loss could worsen the illness. Neither punishment nor treatment of an assumed uterine defect addresses a properly established mental disorder.

Modern correction: assess risk and distinguish primary psychiatric illness from a medical emergency. Consider bipolar disorder, medication- or substance-related illness, thyroid disease, neurological disease and infection. After childbirth, distinguish postpartum psychosis from delirium due to sepsis, metabolic disturbance or another obstetric complication. Protect the woman and baby while arranging prompt specialist assessment. NICE recommends immediate assessment, within four hours of referral, for sudden symptoms suggesting postpartum psychosis.^[ref]

For established mania, current treatment may include an appropriate antipsychotic, specialist use of a mood stabilizer, and review of medicines such as an antidepressant that may be contributing. Pregnancy, breastfeeding, previous treatment response, physical disease and monitoring requirements affect the choice. In severe or treatment-resistant illness, additional specialist interventions may be needed. Treat delirium by addressing its physical cause alongside safe supportive care; it is not interchangeable with a manic episode.^[ref][ref] The organizing principle is a diagnosis and a safe care plan, not a presumption that all acute behavioural change in a woman is “uterine mania”.