= Case reproduction number
{title2=$R_t^{\mathrm{case}}$}
The <case reproduction number> is the expected number of secondary <infections> actually generated by a person infected at time $t$, allowing transmission conditions to change during that person's infectious lifetime. It follows an infection cohort through the subsequent conditions it experiences. The <instantaneous reproduction number> instead freezes conditions at the reference time. Cori and colleagues distinguish these two constructions in their framework for <time-varying reproduction numbers>. https://pubmed.ncbi.nlm.nih.gov/24043437/[Cori et al., A new framework and software to estimate time-varying reproduction numbers during epidemics, 2013]{ref}.
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