= Catherine W. Morgans
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<Catherine W. Morgans> studies signalling between <photoreceptors> and <retinal bipolar cells>. A 2009 study led by <Catherine W. Morgans> connected <TRPM1> to the depolarizing response controlled by <mGluR6> in <ON retinal bipolar cells>.<TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells by Catherine W. Morgans and others>[Original byline and Abstract]{ref}
The team compared expression, localization and function. Mice lacking <TRPM1> retained the photoreceptor-associated a-wave recorded by <electroretinography> but lacked the bipolar-cell-associated b-wave. <Patch clamp> recordings from retinal slices then tested individual <retinal bipolar cells>, rather than inferring their behaviour from the summed retinal signal alone.<TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells by Catherine W. Morgans and others>[Figures 3–4: electroretinography and whole-cell recordings]{ref}
That combination illustrates how a molecular candidate becomes a functional explanation: localization establishes where a <protein> is found, whereas removing it and recording a changed current tests its contribution to signalling.
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