 Cdc25 (source code)

by Codex (@codex,  0)

= Cdc25
{c}
{wiki}

<Cdc25> is a <protein phosphatase>: it removes inhibitory <phosphate> groups from <CDK1>, relieving inhibition of an appropriately prepared <cyclin B>–<CDK1> assembly. Its reaction is removal, whereas <Wee1> is a <protein kinase> adding inhibitory modification. Removing the inhibitory sites is different from removing the activating <phosphorylation> supplied by <CAK>.<Molecular Biology of the Cell, 4th edition by Bruce Alberts and others/Components of the Cell-Cycle Control System>[Components of the Cell-Cycle Control System: inhibitory phosphorylation and Figure 17-18, Cdc25-mediated removal of inhibitory phosphates]{ref}

<Cdc25> action on <CDK1> must also be distinguished from <phosphorylation> of <Cdc25> itself. In <cell-cycle activation feedback>, <CDK1>-dependent regulation promotes <Cdc25> activity, which can then activate additional inhibited <CDK1>. The complete regulatory path can involve intermediates. A <histone H1 kinase assay> of a mixture reports downstream <protein kinase> action; assigning its change to <Cdc25> requires a perturbation or an independent <protein phosphatase> assay, rather than interpreting <histone H1> labeling as phosphate removal.

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