Cdc45
= Cdc45
{c}
A component of the active <eukaryotic> CMG replicative helicase.
It works with <MCM2-7> and <GINS> in the <CMG helicase>. Assembly and activation of this complex connect licensed replication origins to an operating fork; the presence of one component on <chromatin> does not alone establish active unwinding. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapters 4–7, chromatin, replication and gene regulation]{ref}