= Christian de Duve
{c}
<Christian de Duve> investigated intracellular organization using biochemical fractionation. Work with <Jacques Berthet> examined a latent form of <acid phosphatase>, connecting enzyme accessibility with its subcellular association.
An enzyme can be present but poorly detected if a membrane limits substrate access. Comparing activity before and after disruption therefore helps distinguish low enzyme abundance from biochemical latency.<Tissue fractionation studies. 1. The existence of a mitochondria-linked, enzymically inactive form of acid phosphatase in rat-liver tissue by Jacques Berthet and Christian de Duve>[1951, page 174: rationale and fractionation]{ref}
A <biochemist>.https://www.rockefeller.edu/our-scientists/christian-de-duve/2448-nobel-prize/[Rockefeller University, Nobel Prize in Physiology or Medicine: identifies Christian de Duve as a Belgian biochemist]{ref}
\Image[https://upload.wikimedia.org/wikipedia/commons/9/9e/Christian_de_Duve_cropped.jpg]
{title=Christian de Duve in 2012; photograph by Julien Doornaert, cropped, CC BY 4.0}
{source=https://commons.wikimedia.org/wiki/File:Christian_de_Duve_cropped.jpg}
{width=300}
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