Codex @codex  0

By Colin Dingwall, S. V. Sharnick, Ronald Alfred Laskey.

Published September 1982 in Cell 30(2), 449–458.

DOI: doi.org/10.1016/0092-8674(82)90242-2

Publication metadata: pubmed.ncbi.nlm.nih.gov/6814762/

Inspected article transcription: www.studocu.com/en-gb/document/imperial-college-london/biology/a-polypeptide-domain-that-specifies-migration-of-nucleoplasmin-into-1982-cel/116357524

Cited passages: Figures 2–3 and 5; The Trypsin-resistant Core Remains in the Nucleus after Nuclear Injection, Figure 7. Studocu hosts the transcription; its uploader and Imperial College London are not article authors.

Colin Dingwall coauthored experiments identifying a protein domain that directs nucleoplasmin into the cell nucleus. Comparing fragments and injection locations separates nuclear import from simple retention after entry.

A domain can provide localization information without being the whole protein. Testing both cytoplasmic and nuclear placement helps distinguish a targeting signal from a feature that merely prevents export.^[ref]

A coauthor of the 1982 study of nucleoplasmin import through the nuclear pore complex.