Exchangeability means that the joint prior law of the hospital risks is unchanged by relabelling hospitals; it permits different realized . We should not assume unconditional exchangeability when known hospital characteristics predict systematic risk differences. Examples include severity and age of patients, elective versus emergency operations, procedure mix, specialist referral status, or a relationship between surgical volume and risk. Mixing such groups in one unconditional prior confounds these differences with unexplained hospital variation.
Use covariates or clinically comparable strata first; only remaining hospital effects might reasonably be exchangeable random variables. This is conditional exchangeability of hospital risks. Different sample sizes alone do not refute exchangeability of the underlying risks, although a known association between size and risk would matter. Nor does variation in the observed death proportions refute exchangeability: sampling variability and genuine random heterogeneity are both allowed.
Do not pool hospitals as exchangeable risks when their known case mix, procedures or other relevant characteristics distinguish their expected risk distributions.