= Conformational entropy
{title2=$S_{\rm conf}=k_B\ln\Omega$}
<Conformational entropy> measures the multiplicity of molecular <conformations> compatible with specified macroscopic constraints. For equally weighted accessible <conformations> it is $k_B\ln\Omega$; for <probabilities> $p_i$, it is $-k_B\sum_i p_i\ln p_i$. A folded <protein> generally has less chain <conformational entropy> than its unfolded ensemble, but folding can still lower total <Gibbs free energy> when solvent and interaction contributions are included.
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