= E. Rodriguez Boulan
{c}
<E. Rodriguez Boulan> is a <cell biology> researcher studying how <epithelial cells> establish and maintain <apical-basal polarity>. The institutional profile links this research to the organization of <membrane proteins> and the physiology of the <retinal pigment epithelium>.<Enrique Rodriguez-Boulan research profile at Weill Cornell Medicine>[Research summary and1978 discovery attribution]{ref}
A 1978 study with <D. D. Sabatini> used the budding of enveloped <viruses> as a visible test of membrane organization. In polarized epithelial monolayers, <Influenza A virus> budded from the <apical membrane>, whereas <vesicular stomatitis virus> acquired its envelope at the <basolateral membrane>. The same <biological cell> could therefore present biologically different surface regions.<Asymmetric budding of viruses in epithelial monlayers: a model system for study of epithelial polarity by E. Rodriguez Boulan and D. D. Sabatini>[Abstract and electron-microscopic observations: virus-specific asymmetric budding]{ref}
The comparison turns an abstract property, <cell polarity>, into a spatially observable event. If two kinds of <virus> leave through different surfaces, the membrane cannot be treated as one uniform bag. The experiment motivates questions about how <proteins> reach the correct membrane region and remain organized there; it does not by itself identify every sorting component.
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