= Epidermal growth factor receptor
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= EGFR
{c}
{synonym}
In an illustrative <EGFR> activation route, <EGF> stabilizes an associated pair of <receptor> chains. Asymmetric contact between their <protein kinase> <protein domains> activates one catalytic partner without requiring its activation-loop <phosphorylation>. Subsequent <phosphorylation> of cytoplasmic tails creates recruitment sites. Preassociated inactive <EGFR> populations can also occur: the cartoon's separated starting chains are not a universal initial condition.<Cell signaling by receptor-tyrosine kinases by Mark A Lemmon and Joseph Schlessinger>[Lemmon and Schlessinger, “Mechanisms of Receptor Activation” and “Allosteric activation of TKDs”, Figure 2F]{ref}
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