= Frequency and isostericity of RNA base pairs by Jesse Stombaugh and others
{c}
{tag=Work by Jesse Stombaugh}
{tag=Work by Craig L. Zirbel}
{tag=Work by Eric Westhof}
{tag=Work by Neocles B. Leontis}
{title2=2009}
https://pubmed.ncbi.nlm.nih.gov/19240142/
https://doi.org/10.1093/nar/gkp011
https://pmc.ncbi.nlm.nih.gov/articles/PMC2673412/
Jesse Stombaugh, Craig L. Zirbel, Eric Westhof and Neocles B. Leontis, Nucleic Acids Research 37(7), 2294–2312 (2009). The paper introduces the IsoDiscrepancy Index and compares RNA base-pair geometry with structural and sequence alignments. Results, Figure 2 and Table 3, calibrate isosteric/near-isosteric thresholds and distinguish differently oriented wobble pairs.
Additional cited passages: The IsoDiscrepancy Index, Definition, explains the C1′/attachment-nitrogen geometry, separate in-plane and flipped alignment cases, and the length interpretation of the rotation coefficients. IDI has units of ångströms; the in-plane rotation angle is multiplied by a 2-ångström length scale and is expressed in radians. Methods selects an observed base-pair exemplar by minimizing the row sum of pairwise discrepancies. Validation of the IDI, Figure 2 and Table 3, gives the study-specific isosteric and near-isosteric cutoffs.
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