Geminin (source code)
= Geminin
A replication-control <protein> whose regulated degradation motif is used in the original <Fucci> reporters.
Its normal role includes restricting <replication licensing> through interaction with <Cdt1>. In a <Fucci> construct, a selected degradation region is used to report regulated turnover; the reporter signal should not be equated with the full native <protein>’s activity. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 17, Control of DNA Replication]{ref}
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