Glucose transport (source code)

= Glucose transport

<Glucose transport> is movement of <glucose> between compartments, commonly across a <cell membrane>. It depends on carrier properties, carrier abundance, <substrate> concentrations and any coupled driving process. In facilitated transport, a simplified saturating relation $J=J_{max}C/(K+C)$ describes initial uptake under specified conditions. At high $C$, additional <substrate> has little effect because carrier capacity is limiting. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 11, Carrier Proteins and Active Membrane Transport]{ref}

Transport and subsequent <metabolism> are separate steps. Phosphorylation of intracellular <glucose> changes the pool available for reverse transport, so measured uptake can depend on both entry and trapping. Likewise, an insulin-induced change in surface <GLUT4> can alter entry without requiring a change in the intrinsic kinetics of each carrier. A tracer accumulation experiment must specify which of these processes contributes to its readout.