 H. Deng (source code)

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= H. Deng
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H. Deng is the first-listed author of a 1996 study identifying <CCR5> as a major <co-receptor> for entry by tested primary <HIV-1> isolates. The work addressed a specific puzzle: <CD4> was a necessary recognition component, but its presence alone did not explain why different <HIV-1> isolates entered different kinds of host <cells>. The paper showed that the <chemokine receptor> then called CC-CKR-5, now <CCR5>, supported entry mediated by the envelopes of primary macrophage-tropic <HIV-1> strains.<Identification of a major co-receptor for primary isolates of HIV-1 by H. Deng and others>[Abstract, Nature 381 (1996), pp. 661–666; DOI 10.1038/381661a0.]{ref}

The useful conceptual example is that a host <cell> can possess <CD4> yet lack the additional receptor combination used by a particular <HIV-1> isolate. The study contrasted this entry pattern with that of viruses adapted to T-cell lines. It therefore established a receptor contribution for specified virus–cell combinations, rather than a rule that one <co-receptor> serves every <HIV-1> isolate. This distinction connects molecular recognition at the <cell membrane> with differences in which <cells> a virus can enter.<Identification of a major co-receptor for primary isolates of HIV-1 by H. Deng and others>[Abstract: comparison of fusin-dependent and CC-CKR-5-dependent entry.]{ref}

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