= H3K27 trimethylation
{c}
= H3K27me3
{c}
{synonym}
<H3K27 trimethylation> adds three <methyl groups> to lysine 27 of <histone H3>, conventionally H3K27me3. It is associated with Polycomb-linked repression of developmental <genes> in many <eukaryotes>. Deposition and removal help regulate the persistence of a <chromatin> state. A broad marked domain describes a molecular state; demonstrating that the mark is required for repression at a particular <gene> needs a perturbation that separates it from associated factors. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 7, Chromatin Structure and Gene Regulation: Polycomb-associated repression]{ref}
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