= Heart development
<Heart development> produces the pumping <organ>, its chambers, lining and supporting structures through coordinated differentiation and <morphogenesis>. The early <heart tube> changes shape through <cardiac looping> and receives further cellular contributions; changes in shape, <cell> number and <cell> identity are separable processes.
In <zebrafish>, fluorescent developmental-timing assays and a <photoconvertible fluorescent protein> distinguished early differentiation from later addition at the <arterial pole of the heart>. These experiments showed why growth of the <heart> cannot be explained solely by division of already differentiated cardiac <cells>.<Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart by Emma de Pater and others>[Summary; transgenic timing and photoconversion assays]{ref}
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