Histone methylation
= Histone methylation
<Histone methylation> adds <methyl groups> to selected residues of <histones>. The position and number of <methyl groups> affect which binding partners recognize the mark. <H3K4 methylation>, <H3K9 methylation> and <H3K27 trimethylation> therefore cannot be treated as one interchangeable signal. Their distributions can be associated with different transcriptional states, and direct causation requires more than correlation between a mark and <gene expression>. <Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi by Thomas A. Volpe and others>[2002, RNA interference and H3K9-linked silencing]{ref}