= J. D. Hoff
{c}
\b[J. D. Hoff] is an author of the 1983 study <Hormonal dynamics at midcycle: a reevaluation by J. D. Hoff and others>, which examined how <hormones> from the <ovary> and <pituitary gland> change around <ovulation>. Its contribution was a time-resolved comparison: samples from five participants were taken at two-hour intervals over five days, allowing changes in <estradiol>, <progesterone>, <luteinizing hormone> and <follicle-stimulating hormone> to be aligned around the onset of the <luteinizing hormone> surge.<Hormonal dynamics at midcycle: a reevaluation by J. D. Hoff and others>[abstract, study design and timing reference]{ref}
That alignment exposed relationships which a single measurement could miss: the surge began abruptly near peak <estradiol>, while the rise in <progesterone> had already begun. The experiment supplied a temporal picture of the <hypothalamic–pituitary–ovarian axis>; temporal association by itself does not prove which change caused another. The cited paper identifies Hoff by initials, which are retained here.
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