= J. O. Bullock
{c}
<J. O. Bullock> studied how <Colicin E1> forms ion-conducting channels in <lipid bilayers>. A 1983 study compared the complete <protein> with a fragment from its <C-terminus>, measuring both individual-channel and aggregate electrical behaviour.<Comparison of the macroscopic and single channel conductance properties of colicin E1 and its COOH-terminal tryptic peptide by J. O. Bullock and others>[Journal of Biological Chemistry258, pp.9908–9912; Abstract and byline]{ref}
The fragment retained properties very similar to those of the complete <Colicin E1>. Both forms could bind a <lipid bilayer> before a suitable <membrane potential> permitted conduction. Fragmentation therefore helped locate a functional region, while electrical measurements distinguished attachment from pore opening. These are separate experimental questions even though both involve the same <protein> at the same membrane.<Comparison of the macroscopic and single channel conductance properties of colicin E1 and its COOH-terminal tryptic peptide by J. O. Bullock and others>[Abstract; terminal fragment and potential-dependent channel formation]{ref}
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