= Kinetochore-microtubule attachment
<Kinetochore-microtubule attachment> mechanically links a <chromosome> to the <spindle apparatus> through its <kinetochore>. An end-on attachment can maintain contact with a <microtubule> while that <microtubule> grows or shortens. For accurate <chromosome segregation>, sister <kinetochores> normally attach toward opposite ends of the <spindle apparatus>; attachment alone does not establish that this geometry is correct. Incorrect attachments can be released and replaced. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 18, Mitosis: kinetochore attachment and chromosome segregation]{ref}
A laser experiment separated an unattached <kinetochore> from the rest of a chromosome. Destroying the last unattached <kinetochore> allowed <anaphase> to begin, whereas control damage to a chromosome arm did not have that effect. This supported an inhibitory signal originating at unattached <kinetochores>, explaining how even one unfinished attachment can delay the division of the whole <cell>. <The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores by Conly L. Rieder and others>[1995, abstract, Table I and laser-ablation experiments]{ref}
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