Lethal giant larvae
= Lethal giant larvae
<Lethal giant larvae> denotes a conserved polarity-protein family first characterized in <Drosophila>. Its members help organize cortical domains and epithelial polarity, with activity and localization regulated partly through <phosphorylation>. Mammalian LLGL <proteins> are related components rather than literal larval structures. Their contribution depends on cellular context, so polarity effects and effects on proliferation should be measured separately. <NCBI Gene by the National Library of Medicine>[Homo sapiens, LLGL1 record, Summary and linked functional evidence]{ref}