Liability-threshold model
= Liability-threshold model
{title2=$D=\mathbf 1\{L>t\}$}
A model in which a binary diagnostic outcome occurs when an underlying continuous liability exceeds a threshold. Genetic and environmental components can influence liability. Estimating liability-scale <heritability> requires assumptions about <prevalence>, ascertainment and the liability distribution; crude diagnostic concordance is not a continuous-trait <correlation>.