= M. L. Dustin
{c}
<M. L. Dustin> is the first author, with <T. A. Springer>, of a 1989 study testing how antigen recognition regulates <T cell> <cell adhesion>. Cross-linking the <T-cell receptor> rapidly increased the strength of adhesion through <LFA-1> to its intercellular binding partners, and the effect was transient.<T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 by M. L. Dustin and T. A. Springer>[Abstract: receptor-triggered signaling, increased adhesion and its time course]{ref}
The experiment distinguishes the amount of a surface molecule from its functional state. A cell can change how effectively an existing adhesion system works after receiving a signal, without that observation requiring a newly made adhesion apparatus. The short-lived response also supplies a way to coordinate recognition, stable contact and later detachment.<T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 by M. L. Dustin and T. A. Springer>[Abstract: dynamic regulation of adhesion and de-adhesion]{ref}
Back to article page
