= M. S. Patterson
{c}
<M. S. Patterson> coauthored the 1989 time-resolved tissue-optics study with <Britton Chance> and <B. C. Wilson>. It used picosecond light pulses and a <diffusion approximation> to infer optical properties from the time dependence of transmitted or backscattered light, comparing the model with preliminary measurements and <Monte Carlo simulations>.<Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties by M. S. Patterson and others>[abstract and published byline]{ref}
The measurement separates effects that an overall brightness reading can mix together. Repeated <light scattering> lengthens photon paths and broadens the arrival-time distribution, while <absorption> suppresses photons along those paths. A pulsed source, a sample and a time-sensitive detector therefore provide more information than a single steady illumination measurement. Inferring coefficients still depends on the geometry and the validity of the transport approximation; pulse timing does not remove the need for a physical model.
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