= Martin Jinek
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Martin Jinek coauthored a 2011 study explaining how <Xrn1> recognizes an <RNA> end and couples <hydrolysis> to continued processing. The <X-ray crystallography> experiment used a truncated, catalytically altered construct bound to <DNA>; complementary biochemical experiments tested <RNA> degradation.<Coupled 5′ nucleotide recognition and processivity in Xrn1-mediated mRNA decay by Martin Jinek and others>[Byline; Results, construct and substrate-complex structure]{ref}
This pairing of methods matters: a bound nucleic-acid segment can reveal contacts near an <active site>, while a degradation assay tests chemical function. Neither a static structure nor a single product measurement independently reveals every step in motion.
For an original structural example, take two hypothetical <RNA-DNA hybrids> with the same $20$ paired positions but different unpaired <RNA> extensions of $3$ and $7$ <nucleotides>. The <RNA> strands contain $23$ and $27$ <nucleotides>, respectively, while both <DNA> partners contain $20$. Equal paired-region length therefore does not mean equal accessibility of the $5'$ end. This accounting illustrates a way of separating paired structure from end geometry, not the actual substrate dimensions used in the paper.
Jinek was also a coauthor of the 2012 demonstration of programmable <Cas9> cleavage, together with <Jennifer A. Doudna> and other collaborators. That work connected <guide RNA> recognition with targeted <DNA> cleavage and showed that the guide functions could be combined in one <RNA> molecule.<A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity by Martin Jinek and others>[Byline, Abstract and Figure 5]{ref}
\Image[https://www.bioc.uzh.ch/dam/jcr%3A5f1132c8-1c83-4fbc-8665-65313c6b3e45/mjinek.jpg]
{title=Martin Jinek, portrait linked from his University of Zurich research-group page}
{description=<Martin Jinek research profile at Zurich>[Named profile and linked portrait]{ref}}
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