= Mary Sue Coleman
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<Mary Sue Coleman> coauthored mutational analysis of active-site residues in human adenosine deaminase. Purified recombinant enzymes and variants were compared for activity, kinetic parameters, and zinc content.
A mutation can change metal binding as well as reaction chemistry. Measuring both helps distinguish loss of a catalytic interaction from loss of a correctly assembled active site.<Mutational analysis of active site residues of human adenosine deaminase by D. Bhaumik and others>[Mutant enzyme kinetics and zinc-content comparisons]{ref}
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