= McDonald-Kreitman test
{c}
{title2=$\alpha=1-D_SP_N/(D_NP_S)$}
A comparison of nonsynonymous and synonymous polymorphism and divergence. Under a simple neutral model their ratios match. An excess of nonsynonymous divergence can support adaptive fixation, but mildly deleterious polymorphism, changing demography and site-class assumptions affect interpretation.<Adaptive protein evolution at the Adh locus in Drosophila by John H. McDonald and Martin Kreitman>[Original polymorphism-divergence test]{ref}
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