MEK (source code)
= MEK
{c}
<MEK> is a mitogen-activated <protein kinase> <protein kinase> that phosphorylates and activates <ERK> in the <RAS-MAPK signalling> pathway. Its dual-specificity chemistry can modify both a threonine and a tyrosine in the activation region of its substrate. <MEK> therefore connects one <protein kinase> tier to the next. When testing developmental requirements with an inhibitor, unchanged fate is informative only if inhibition of the downstream pathway has been established. <Enzyme Nomenclature by the IUBMB>[EC 2.7.12.2, mitogen-activated protein kinase kinase]{ref}
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