Munc18 (source code)
= Munc18
{c}
<Munc18> denotes a Sec1-Munc18 family of <proteins> that regulate <SNARE>-dependent <membrane fusion>. Different isoforms interact with particular syntaxin-associated pathways; Munc18-1 is prominent in neuronal secretion, while Munc18c participates in other trafficking systems. Binding to a syntaxin and promoting productive fusion are separable activities. Reconstitution experiments test how these regulators favour assembly of the appropriate fusion machinery. <Selective activation of cognate SNAREpins by Sec1-Munc18 proteins by Jingshi Shen and others>[2007, purified SNARE fusion systems and cognate SM-protein effects]{ref}
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