= Neuregulin 1
= NRG1
{c}
{synonym}
<Neuregulin 1> is a signaling <protein> <ligand> acting through <ErbB receptors>. The human NRG1 <gene> produces several <protein isoforms> through alternative promoter usage and <alternative splicing>; these products differ in their structure and tissue distribution.<NCBI Gene by the National Library of Medicine>[Human NRG1, Gene ID 3084, RefSeq summary: cell-cell signaling and tissue-specific isoforms]{ref}
Its developmental roles include <ventricular trabeculation>. A targeted mutation in mice revealed that loss of <neuregulin 1> disrupts normal development of several organ systems, providing experimental evidence of requirement rather than expression alone.<Multiple essential functions of neuregulin in development by Dirk Meyer and Carmen Birchmeier>[1995, neuregulin-null embryonic phenotypes]{ref}
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