Nuclear localization sequence (source code)

= Nuclear localization sequence
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= Nuclear localization signal
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= NLS
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A <nuclear localization sequence> is an ordered stretch of <amino acid residues> that can direct <protein> import into a <cell nucleus>. In the classical pathway, <importin> α recognizes the <nuclear localization sequence>, and <importin> β mediates passage through the <nuclear pore complex>. Other recognition pathways exist. An exposed <nuclear localization sequence> is a targeting feature, not a guarantee of import under every condition.<The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper>[Selective Transport of Proteins to and from the Nucleus, Figure 8.9; Regulation of Nuclear Protein Import]{ref}

<RNA> export is a different cargo pathway: <RNA> travels associated with <proteins>, as a <ribonucleoprotein>, rather than being imported by its own <nuclear localization sequence>. Export of <messenger RNA> connects nuclear <transcription> to cytoplasmic <biological translation>.<The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper>[Transport of RNAs, opening paragraphs]{ref}