= Oxaloacetate
<Oxaloacetate> is a four-carbon dicarboxylate with a <ketone> group adjacent to one carboxylate. It is regenerated in the <citric acid cycle> rather than consumed as a net reactant on every turn.
Condensation with <acetyl-CoA> forms <citrate>; later oxidation of <malate> regenerates <oxaloacetate>. Removing <oxaloacetate> for biosynthesis therefore requires replenishing the cycle's intermediates to sustain flux.<The citric acid cycle by Hans Adolf Krebs>[Table 1 and discussion of the catalytic cycle]{ref}
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