= Solution
A <steroid hormone> crosses the <lipid bilayer> and binds an intracellular <nuclear receptor>. For a cytoplasmic <glucocorticoid receptor>, ligand binding alters association with <molecular chaperones>, exposes nuclear-targeting functions and promotes accumulation in the <cell nucleus>. Other <steroid hormone> receptors already have substantial nuclear localization. The activated <receptor> binds specific <hormone response elements> in <DNA>, often as a dimer, and changes recruitment of <transcription coactivators> or <transcription corepressors>. These factors alter local <chromatin> and recruitment or activity of the <RNA polymerase II> machinery. \b[The result is selective activation or repression of target <genes>], followed by altered <messenger RNA> and <protein> abundance; the <hormone> itself does not act as an <RNA polymerase> or directly rewrite the <DNA> sequence.
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